I'm pretty unconvinced by people self medicating or going to "shamans" and the like. I think many drugs have valid therapeutic uses and many are more effective and do less harm than traditional medical drugs.
A conversation
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you consume caffeine and l-theanine both substances that alter the mind, just in subtler ways.
MDMA & psilocybin have been life-changing for me and many others, and I use them less than once a year.
ketamine's just for funsies though :-)